León, H.H.; Melo, C.E.; Ramírez, J.F. (2012). Role of the myokines production through the exercise. Journal of Sport and Health Research. 4(2):157-166.



In the last decade skeletal muscle is no longer seen as just a contractile organ for the movement a body, to be considered a highly active endocrine organ, producing by the exercise multiple hormones with endocrine and paracrine action called Myokines. Some of this Myokines are involved in the modulation of inflammatory processes as does Interleukin 6 (IL6), others contribute to the regulation of metabolism, increasing lipolysis and improving insulin sensitivity such as IL6, IL15, BDNF, FGF21 and visfatin and other hormones through its paracrine action contribute in muscular adaptation as IL8, LIF and FGF21. Adipose tissue produce hormones called Adipokines, that change (damage or alter) muscle metabolism, these are considered antagonistic to Myokines in function. It is important to understand the role of Myokines to intervene through the exercise in a better way to manage the most prevalent diseases in the world as obesity and diabetes


Adipokines, Exercise, Chronic inflammation, Myokines


Journal of Sport and Health Research - 2009